Titles

  • Research member at the Montreal Cancer Institute
  • Assistant Professor, Department of Hematology & Oncology, Université de Montréal
  • Medical Oncologist
  • Clinician Scientist, Cancer Axis, CHUM Research Center

Research Angle

We are a translational oncology lab focused on targeted approaches in lung cancer and melanoma:

  • We develop novel biomarkers to cancer therapy by studying the tumor microenvironment and using next-generation sequencing. Our group develops in vitro and in vivo patient-derived models to answer clinical questions in oncology.
  • We also design and lead early phase I and randomized phase II microbiome-centered clinical trials.

Laboratory Team

  • Gabryella Pinheiro, Postdoctoral Research Fellow

Recent Publications

  1. Immune-related colitis is associated with fecal microbial dysbiosis and can be mitigated by fecal microbiota transplantation
  2. Efficacy of PD-(L)1 blockade monotherapy compared with PD-(L)1 blockade plus chemotherapy in first-line PD-L1-positive advanced lung adenocarcinomas: a cohort study
  3. Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification
  4. Combination of Osimertinib and Dacomitinib to Mitigate Primary and Acquired Resistance in EGFR-Mutant Lung Adenocarcinomas
  5. The negative impact of antibiotics on outcomes in cancer patients treated with immunotherapy: a new independent prognostic factor?

Pubmed Page

Full Bibliography

Email address for application

Arielle.elkrief.med@ssss.gouv.qc.ca

Biography

Arielle Elkrief, MD is a medical oncologist and clinician scientist specializing in the care of patients with lung cancer and melanoma. After completing her medical oncology specialization at McGill University, she completed a research fellowship at Memorial Sloan Kettering Cancer Center in New York. There, she focused on functional genomic approaches and developed new biomarkers and treatments for patients with cancer. Dr. Elkrief also serves as the Medical Director for the CHUM Microbiome Centre where she designs clinical trials that are focused on the gut microbiome.