The team of Francis Rodier, a research member at the Institute, shows that cellular aging, which protects against cancer, depends on a mechanism of genomic instability causing the disease.
The research team published a study in Nucleic Acids Research showing, for the first time, that “cellular senescence”, a state reached when aging cells stop dividing, is caused by irreparable damage to the genome rather than by telomere erosion alone. This discovery was made possible, in part, by state-of-the-art imaging equipment funded by the Montreal cancer Institute. It goes against the popular scientific model of the last 15 years.
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