Diane Provencher

Titles

• Researcher – Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM) – Cancer Axis
• Research member – Montreal Cancer Institute
• Full Professor – Department of Obstetrics and Gynecology, Division of Gyne-Oncology, Faculty of Medicine, Université de Montréal

Research angle

Dr. Provencher’s research projects are in the field of gyneco-oncology. She has a strong interest in basic and translational studies of genetic and epigenetic events related to epithelial ovarian cancer. Dr. Provencher has extensive experience in cell culture and mouse xenograft models. She has been involved in the development of several spontaneously immortalized cell lines from ovarian cancer, as well as primary cultures, 3D spheroid models, and more recently ex-vivo microdissected tissues grown on a microfluidic platform. Dr. Provencher is also involved in the creation and maintenance of an extensive ovarian tissue bank of fresh frozen samples of normal ovaries, benign and tumor tissues, primary cultures derived from cancer tissues, and fixed and paraffin-embedded samples. In addition, Dr. Provencher is very active in Phase I, Phase II and Phase III clinical trials.

Laboratory Team

Basic and Translational Research

• Adriana Orimoto, Research Assistant
• Alexandre Sauriol, PhD Student
• Alexandria Aubourg, Research Coordinator
• Benjamin Péant, Research Associate
• Cecilia Vargas, Research Assistant
• Chantale Auger, Research Assistant
• Christine Caron, Research Assistant
• Claudia Syed, Research Assistant
• Euridice Carmona, Research Associate
• Geneviève Cormier, Research Assistant
• Jennifer Kendall-Dupont, Research Assistant
• Kayla Simeone, PhD Student
• Kim Leclerc-Desaulniers, Animal Health Technician
• Kossay Zaoui, Research Assistant
• Laudine Desreumaux-Communal, Research Assistant
• Liliane Meunier, Research Assistant
• Lise Portelance, Research Assistant
• Manon de Ladurantaye, Research Assistant
• Melica Nourmoussavi, Student M. Sc.
• Mélanie Morin, Research Assistant
• Nathalie Delvoye, Research Assistant
• Renée Bernatchez, Research Assistant
• Véronique Barrès, Research Assistant
• Véronique Ouellet, Research Associate
• Zied Boudhraa, Post-doctoral fellow

Clinical Research

• Bonny Choy, Research Coordinator
• Charles Thivierge, Research Agent
• Elise de Castro Hillmann, Research Agent
• Erica Taupier-Noël, Research Coordinator
• France Gauthier, Research Agent
• Geneviève St-Onge, Research Agent
• Josée Tremblay, Research Nurse
• Lynda Abdelguerfi, Research Agent
• Lyne Girard, Research Assistant
• Nathalie Grenier, Research Nurse
• Silvane Da Silva De Souza, Research Agent
• Shirley Truchon, Research Nurse
• Walid El Abyad, Research Agent

Recent Publications

1. Communal L, Medrano M, Sircoulomb F, Paterson J, Köbel M, Rahimi K, Hoskins P, Tu D, Lheureux S, Oza A, Ailles L, Provencher D, Rottapel R, Mes-Masson AM. Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa. Mod Pathol. 2020 Nov; 33(11):2361-2377.
2. Oza AM, Estevez-Diz M, Grischke EM, Hall M, Marmé F, Provencher D, Uyar D, Weberpals JI, Wenham RM, Laing N, Tracy M, Freshwater T, Lee MA, Liu J, Qiu J, Rose S, Rubin EH, Moore K. A Biomarker-enriched, Randomized Phase II Trial of Adavosertib (AZD1775) Plus Paclitaxel and Carboplatin for Women with Platinum-sensitive TP53-mutant Ovarian Cancer. Clin Cancer Res. 2020 Sep 15; 26(18):4767-4776.
3. Sauriol A, Simeone K, Portelance L, Meunier L, Leclerc-Desaulniers K, de Ladurantaye M, Chergui M, Kendall-Dupont J, Rahimi K, Carmona E, Provencher DM, Mes-Masson AM. Modeling the Diversity of Epithelial Ovarian Cancer through Ten Novel Well Characterized Cell Lines Covering Multiple Subtypes of the Disease. Cancers (Basel). 2020 Aug 8; 12(8):2222.
4. Del Campo JM, Matulonis UA, Malander S, Provencher D, Mahner S, Follana P, Waters J, Berek JS, Woie K, Oza AM, Canzler U, Gil-Martin M, Lesoin A, Monk BJ, Lund B, Gilbert L, Wenham RM, Benigno B, Arora S, Hazard SJ, Mirza MR. Niraparib Maintenance Therapy in Patients With Recurrent Ovarian Cancer After a Partial Response to the Last Platinum-Based Chemotherapy in the ENGOT-OV16/NOVA Trial. J Clin Oncol. 2019 Nov 10; 37(32):2968-2973.
5. Cheasley D, Wakefield MJ, Ryland GL, Allan PE, Alsop K, Amarasinghe KC, Ananda S, Anglesio MS, Au-Yeung G, Bohm M, Bowtell DDL, Brand A, Chenevix-Trench G, Christie M, Chiew YE, Churchman M, DeFazio A, Demeo R, Dudley R, Fairweather N, Fedele CG, Fereday S, Fox SB, Gilks CB, Gourley C, Hacker NF, Hadley AM, Hendley J, Ho GY, Hughes S, Hunstman DG, Hunter SM, Jobling TW, Kalli KR, Kaufmann SH, Kennedy CJ, Kobel M, Le Page C, Li J, Lupat R, McNally OM, McAlpine JN, Mes-Masson AM, Mileshkin L, Provencher DM, Pyman J, Rahimi K, Rowley SM, Salazar C, Samimi G, Saunders H, Semple T, Sharma R, Sharpe AJ, Stephens AN, Thio N, Torres MC, Traficante N, Xing Z, Zethoven M, Antill YC, Scott CL, Campbell IG, Gorringe KL. The molecular origin and taxonomy of mucinous ovarian carcinoma. Nat Commun. 2019 Sep 2; 10(1):3935.

Pubmed Page

https://pubmed.ncbi.nlm.nih.gov/?term=provencher+d&sort=date

Biography

Dr. Provencher began her medical training at the Université de Montréal in 1974 before completing her residency in Obstetrics and Gynecology at McGill University. Following an initial experience as a clinical assistant in the Department of Obstetrics and Gynecology at McGill University, she completed two postdoctoral fellowships at Jackson Memorial Hospital (University of Miami) and Memorial Sloan Kettering Cancer Institute in New York from 1986 to 1989. Upon her return to Quebec, Dr. Provencher joined the Division of Gyneco-Oncology of the Department of Obstetrics and Gynecology at the Université de Montréal in 1989, where she became a Clinical Associate and Professor in 2001. At the same time, and since 1990, Dr. Provencher has been involved in clinical and translational research in obstetrics and gynecology at the Centre Hospitalier de l’Université de Montréal (CHUM) and at the Institut du cancer de Montréal (ICM). That same year, a “magical” meeting with Dr. Anne-Marie Mes-Masson led to the establishment of a clinical-fundamental collaboration on ovarian cancer. In 2000, she became the head of the CHUM Family Cancer Clinic (breast-ovarian), a position she still holds today. Head of the gyneco-oncology department at the CHUM from 2001 to 2011, Dr. Provencher has also been the coordinator of clinical research activities in gyneco-oncology since 2001. It was a magical meeting in 1990 with Anne-Marie Mes-Masson that triggered a magical clinical-fundamental collaboration on ovarian cancer. Her greatest achievements include the involvement of patients in research and the support of the community of Rallye Spyder Défi members, Anne-Marie Chagnon’s jewelry and key people such as Michèle, Sylvie, Lucie, Suzanne and many others…